A study at UCSF showed a two-fold increase in risk for dementia in those who had reported a hypoglycemic event, in this 12-year prospective trial. The author, Kristine Yaffe, MD, also reported there is a bi-directional relationship between hypoglycemia and dementia in that those with dementia were also at increased risk for hypoglycemic events. This research finding is consistent with previous reports linking hypoglycemia with dementia.
The authors suggest a patient-centered approach to glycemic control taking into account the possible harms from hypoglycemia. If the person with diabetes is at risk for hypoglycemia then it may be in their best interests to set a higher target HgbA1C.
This finding was reported in Endocrine Today, July 2013.