The FDA released an alert today (8/24/2011) warning against the use of Celexa (citalopram), a drug used to treat depression, at doses greater than 40mg per day due to a risk of abnormal heart rhythms. The drug, at doses greater than 40mg per day, is linked with QT interval widening, a term that describes how an electrical pattern in the heart as the large chambers of the heart contract, widens can leads to premature electrical activity in the ventricles. QT interval widening is associated with possible fatal cardiac arrhythmias. People taking Celexa (citalopram) at doses greater than 40mg per day should contact their physician or practitioner that prescribed the drug.
Also of interest, is that the drug is not shown to be anymore effective for managing depression at doses greater than 40mg per day.
The link to the FDA alert is: