Aricept Causes Urinary Incontinence
It is well established that memory health drugs, which includes Aricept, Exelon and Razadyne (galantamine), are each a major risk factor for developing urinary incontinence. The literature shows that people taking these drugs are 1.5 times more likely to be prescribed a drug for urinary incontinence, such as Detrol, Ditropan (oxybutynin), Vesicare, Enablex or others. If this is the case you should understand that using the bladder health drug to manage the incontinence may, in fact, negate the benefits of the memory health drug completely or to some extent. Non-drug interventions for incontinence is perhaps your most beneficial first approach before considering a bladder health drug. If nighttime incontinence is the major concern, try taking Aricept in the morning. This may lessen the nighttime awakenings to go to the bathroom, which may also improve on your quality of sleep and reduce your risk of falling. Other things to consider are whether the memory health drug is truly of benefit. In most instances these drugs provide modest benefits, and not in all people. A thoughtful review should occur with the prescribing physician to determine if the memory health drug is accomplishing what it was intended to do. Lastly, let’s see if there are other medications that are possibly contributing to memory loss or causing it all together. Read our blog on statins associated with memory loss.
| Print article | This entry was posted by Alan Lukazewski on May 15, 2010 at 1:45 pm, and is filed under Adverse Drug Events. Follow any responses to this post through RSS 2.0. You can leave a response or trackback from your own site. |





about 1 year ago
It is a concern that most alzheimer residents have urinary incontinence and are on a “memory drug” such as aricept. Is there an alternative medication? I agree that someone…. maybe NOT the physician, maybe the family member or the resident’s caretaker is the person who needs to decide whether the aricept is beneficial when considering the ramifications of taking the drug.
Thanks for providing current, concise information from the literature. This information is an eye-opener!
about 1 year ago
Yes, Alzheimer’s disease is associated with urinary incontinence yet we must always try to deduce if the drug therapy is the cause or worsening existing incontinence. The primary concern is that a bladder health drug, such as Detrol or Ditropan, may be prescribed as a result. These drugs antagonize the beneficial effects of Aricept and can also cause or worsen cognitive impairment. This type of prescribing is referred to as a “negative prescribing cascade”. Lastly, if nighttime incontinence is the major concern, one can try dosing the Aricept in the morning and not at bedtime since the peak effects of the drug correlate with plasma levels which peak between 3 and 6 hours.
In the management of moderate to severe Alzheimer’s disease we do have the option of Namenda.